-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, Do8bDSTAJYb3gXZuiUJlbNtv4TkG2DYlXrxPStRnWxMyQKFGT539vakCyKHbszrc p6b459u3jBsHSaQKDovcCQ== 0000950142-04-000477.txt : 20040217 0000950142-04-000477.hdr.sgml : 20040216 20040217163447 ACCESSION NUMBER: 0000950142-04-000477 CONFORMED SUBMISSION TYPE: SC 13G/A PUBLIC DOCUMENT COUNT: 4 FILED AS OF DATE: 20040217 GROUP MEMBERS: FRANK H. PEARL GROUP MEMBERS: GEORGE SOROS GROUP MEMBERS: PERSEUS BIOTECH FUND PARTNERS, LLC GROUP MEMBERS: PERSEUS EC, L.L.C. GROUP MEMBERS: PERSEUS-SOROS BIOPHARMACEUTICAL FUND, L.P. GROUP MEMBERS: PERSEUS-SOROS PARTNERS, LLC GROUP MEMBERS: PERSEUSPUR, LLC GROUP MEMBERS: SFM AH LLC GROUP MEMBERS: SFM PARTICIPATION, L.P. GROUP MEMBERS: SOROS FUND MANAGEMENT LLC SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: ALLOS THERAPEUTICS INC CENTRAL INDEX KEY: 0001097264 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 541655029 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A SEC ACT: 1934 Act SEC FILE NUMBER: 005-60251 FILM NUMBER: 04609298 BUSINESS ADDRESS: STREET 1: 11080 CIRCLEPOINT ROAD STREET 2: SUITE 200 CITY: WESTMINSTER STATE: CO ZIP: 80020 BUSINESS PHONE: 3034266262 MAIL ADDRESS: STREET 1: 7000 NORTH BROADWAY STREET 2: SUITE 400 CITY: DENVER STATE: CO ZIP: 80221 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: SOROS GEORGE CENTRAL INDEX KEY: 0000900203 STANDARD INDUSTRIAL CLASSIFICATION: UNKNOWN SIC - 0000 [0000] STATE OF INCORPORATION: NY FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G/A BUSINESS ADDRESS: STREET 1: 888 SEVENTH AVENUE STREET 2: 33RD FLOOR CITY: NEW YORK STATE: NY ZIP: 10106 BUSINESS PHONE: 212-262--6 MAIL ADDRESS: STREET 1: 888 SEVENTH AVE STREET 2: 33RD FLR CITY: NEW YORK STATE: NY ZIP: 10106 SC 13G/A 1 sc13ga1-allos.txt AMENDMENT NO. 1 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* ALLOS THERAPEUTICS, INC. ------------------------ (Name of Issuer) COMMON STOCK, PAR VALUE $.01 PER SHARE -------------------------------------- (Title of Class of Securities) 019777101 --------- (CUSIP Number) DECEMBER 31, 2003 ----------------- (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [_] Rule 13d-1(b) [X] Rule 13d-1(c) [_] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. The information required on the reminder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). CUSIP NO. 019777101 Schedule 13G Page 2 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Perseus-Soros BioPharmaceutical Fund, L.P. - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 2,500,000 Beneficially (6) Shared Voting Power 0 Owned by Each (7) Sole Dispositive Power 2,500,000 Reporting Person (8) Shared Dispositive Power 0 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person PN - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 3 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Perseus-Soros Partners, LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 2,500,000 Beneficially (6) Shared Voting Power 0 Owned by Each (7) Sole Dispositive Power 2,500,000 Reporting Person (8) Shared Dispositive Power 0 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person OO - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 4 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Perseus BioTech Fund Partners, LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 0 Beneficially (6) Shared Voting Power 2,500,000 Owned by Each (7) Sole Dispositive Power 0 Reporting Person (8) Shared Dispositive Power 2,500,000 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person OO - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 5 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person SFM Participation, L.P. - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 0 Beneficially (6) Shared Voting Power 2,500,000 Owned by Each (7) Sole Dispositive Power 0 Reporting Person (8) Shared Dispositive Power 2,500,000 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person PN - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 6 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person SFM AH LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 0 Beneficially (6) Shared Voting Power 2,500,000 Owned by Each (7) Sole Dispositive Power 0 Reporting Person (8) Shared Dispositive Power 2,500,000 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person OO - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 7 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Perseus EC, L.L.C. - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 331,850 (1) Beneficially (6) Shared Voting Power 2,500,000 (1) Owned by Each (7) Sole Dispositive Power 331,850 (1) Reporting Person (8) Shared Dispositive Power 2,500,000 (1) - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,831,850 (1) - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 9.1% - -------------------------------------------------------------------------------- 12. Type of Reporting Person OO - -------------------------------------------------------------------------------- - ------------------------ (1) See Item 4 herein. CUSIP NO. 019777101 Schedule 13G Page 8 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Perseuspur, LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 331,850 (1) Beneficially (6) Shared Voting Power 2,500,000 (1) Owned by Each (7) Sole Dispositive Power 331,850 (1) Reporting Person (8) Shared Dispositive Power 2,500,000 (1) - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,831,850 (1) - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 9.1% - -------------------------------------------------------------------------------- 12. Type of Reporting Person OO - -------------------------------------------------------------------------------- - ------------------------ (1) See Item 4 herein. CUSIP NO. 019777101 Schedule 13G Page 9 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Frank H. Pearl (in the capacity described herein) - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization United States - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 660,100 (1) Beneficially (6) Shared Voting Power 2,500,000 (1) Owned by Each (7) Sole Dispositive Power 660,100 (1) Reporting Person (8) Shared Dispositive Power 2,500,000 (1) - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 3,160,100 (1) - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [_] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 10.2% - -------------------------------------------------------------------------------- 12. Type of Reporting Person IN - -------------------------------------------------------------------------------- - ------------------------ (1) See Item 4 herein. CUSIP NO. 019777101 Schedule 13G Page 10 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person George Soros (in the capacity described herein) - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization United States - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 0 Beneficially (6) Shared Voting Power 2,500,000 Owned by Each (7) Sole Dispositive Power 0 Reporting Person (8) Shared Dispositive Power 2,500,000 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person IA - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 11 of 26 - -------------------------------------------------------------------------------- 1. Name of Reporting Person S.S. or I.R.S. Identifica- tion No. of Above Person Soros Fund Management LLC - -------------------------------------------------------------------------------- 2. Check the Appropriate Box (a) [_] if a Member of a Group (b) [X] - -------------------------------------------------------------------------------- 3. S.E.C. Use Only - -------------------------------------------------------------------------------- 4. Citizenship or Place of Organization Delaware - -------------------------------------------------------------------------------- Number of Shares (5) Sole Voting Power 0 Beneficially (6) Shared Voting Power 2,500,000 Owned by Each (7) Sole Dispositive Power 0 Reporting Person (8) Shared Dispositive Power 2,500,000 - -------------------------------------------------------------------------------- 9. Aggregate Amount Beneficially Owned by Each Reporting Person 2,500,000 - -------------------------------------------------------------------------------- 10. Check if the Aggregate Amount in Row (9) Excludes Certain Shares [X] - -------------------------------------------------------------------------------- 11. Percent of Class Represented by Amount in Row 9 8.0% - -------------------------------------------------------------------------------- 12. Type of Reporting Person OO; IA - -------------------------------------------------------------------------------- CUSIP NO. 019777101 Schedule 13G Page 12 of 26 Item 1. (a) NAME OF ISSUER Allos Therapeutics, Inc. (the "Company"). (b) ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES 11080 Circlepoint Road, Suite 200 Westminster, CO 80020 Item 2. (a) NAMES OF PERSONS FILING This Statement is being filed on behalf of each of the following persons (collectively, the "Reporting Persons") (i) Perseus-Soros BioPharmaceutical Fund, L.P., a Delaware limited partnership (the "Purchaser"); (ii) Perseus-Soros Partners, LLC, a Delaware limited liability company ("PSP GP" and general partner of Purchaser); (iii) Perseus BioTech Fund Partners, LLC, a Delaware limited liability company ("PBFP Partners" and managing member of PSP GP); (iv) SFM Participation, L.P., a Delaware limited partnership ("SFM Participation" and managing member of PSP GP); (v) SFM AH LLC, a Delaware limited liability company ("SFM AH" and general partner of SFM Participation); (vi) Perseus EC, L.L.C., a Delaware limited liability company ("Perseus EC" and managing member of PBFP Partners); (vii) Perseuspur, LLC, a Delaware limited liability company ("Perseuspur" and member of Perseus EC); (viii) Mr. Frank H. Pearl ("Mr. Pearl" and sole member of Perseuspur); (ix) Mr. George Soros ("Mr. Soros" and Chairman of SFM LLC); and (x) Soros Fund Management LLC, a Delaware limited liability company ("SFM LLC" and the sole managing member of SFM AH). (b) ADDRESS OF PRINCIPAL BUSINESS OFFICE The address and principal business offices of (i) Purchaser and (ii) PSP GP is 888 Seventh Avenue, 29th Floor, New York, NY 10106. The address of the principal business offices of (i) PBFP Partners, (ii) Perseus EC, (iii) Perseuspur and (v) Mr. Pearl is 2099 Pennsylvania Avenue, Suite 900, Washington, DC 20006-1813. CUSIP NO. 019777101 Schedule 13G Page 13 of 26 The address of the principal business offices of (i) PSFM Participation, (ii) SFM AH, (iii) Mr. Soros and (iv) SFM LLC is 888 Seventh Avenue, 33rd Floor, New York, NY 10106. (c) CITIZENSHIP (i) Purchaser - a Delaware limited partnership (ii) PSP GP - a Delaware limited liability company (iii) PBFP Partners - a Delaware limited liability company (iv) SFM Participation - a Delaware limited partnership (v) SFM AH - a Delaware limited liability company (vi) Perseus EC - a Delaware limited liability company (vii) Perseuspur - Delaware limited liability company (viii) Mr. Pearl - United States (ix) Mr. Soros - United States (x) SFM LLC - a Delaware limited liability company (d) TITLE OF CLASS OF SECURITIES Common Stock, par value $.01 per share (the "Common Stock" or "Shares") (e) CUSIP NUMBER 019777101 Information contained herein concerning SFM Participation, SFM AH, SFM LLC and Mr. Soros has been provided by SFM LLC. The Purchaser, PSP GP, PBFP Partners, Perseus EC, Perseuspur and Mr. Pearl assume no responsibility for such information. Information contained herein concerning PBFP Partners, Perseus EC, Perseuspur and Mr. Pearl has been provided by each such Reporting Person. The Purchaser, PSP GP, SFM Participation, SFM AH, SFM LLC and Mr. Soros assume no responsibility for such information. Item 3. This statement is not being filed pursuant to either Rule 13d-1(b) or 13d-2(b) or (c). Item 4. OWNERSHIP. (a) AMOUNT BENEFICIALLY OWNED: Each of the Reporting Persons, other than Mr. Pearl, Perseus EC and Perseuspur, may be deemed to beneficially own an aggregate of 2,500,000 Shares. Mr. Pearl may be deemed to beneficially own an aggregate of 3,160,100 Shares as a result of his voting and dispositive power over the 2,500,000 Shares owned by the Purchaser, an additional 328,250 Shares beneficially owned by Perseus Capital, LLC, a Delaware limited liability CUSIP NO. 019777101 Schedule 13G Page 14 of 26 company ("Perseus Capital"), and 331,850 Shares beneficially owned by Perseus 2000, L.L.C., a Delaware limited liability company ("Perseus 2000"). Perseus EC and Perseuspur may be deemed to beneficially own an aggregate of 2,831,850 Shares as a result of their voting and dispositive power over the 2,500,000 Shares owned by the Purchaser and the 331,850 Shares beneficially owned by Perseus 2000. Perseus Capital and Perseus 2000 may be deemed to be affiliates of Mr. Pearl, Perseus EC and Perseuspur. (b) PERCENTAGE OWNED: Based on calculations made in accordance with Rule 13d-3(d), and there being 31,087,004 Shares outstanding as of this date, each of the Reporting Persons, other than Mr. Pearl, Perseus EC and Perseuspur, may be deemed to beneficially own approximately 8.0% of the outstanding Common Stock. Based on calculations made in accordance with Rule 13d-3(d), and there being 31,087,004 Shares outstanding as of this date, Mr. Pearl, Perseus EC and Perseuspur may be deemed to beneficially own approximately 10.2%, 9.1% and 9.1%, respectively, of the outstanding Common Stock. (c) NUMBER OF SHARES AS TO WHICH SUCH PERSON HAS: (i) Each of the Purchaser and PSP GP may be deemed to have sole power to direct the voting and disposition of the 2,500,000 Shares beneficially owned by the Purchaser. Each of Mr. Pearl, Perseus EC and Perseuspur may be deemed to have sole power to direct the voting and disposition of the 331,850 Shares beneficially owned by Perseus 2000. Mr. Pearl may be deemed to have the sole power to direct the voting and disposition of the 328,250 Shares beneficially owned by Perseus Capital. (ii) By virtue of the relationships between and among the Reporting Persons as described in Item 2, each of the Reporting Persons, other than the Purchaser and PSP GP, may be deemed to share the power to direct the voting and disposition of the 2,500,000 Shares beneficially owned by the Purchaser. The Purchaser, PSP GP, PBFP Partners, SFM Participation, SFM AH, Mr. Soros and SFM LLC disclaim beneficial ownership of the 328,250 and the 331,850 Shares beneficially owned by Perseus Capital and Perseus 2000, respectively. Item 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS Not applicable. CUSIP NO. 019777101 Schedule 13G Page 15 of 26 Item 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON The partners of the Purchaser have the right to participate in the receipt of dividends from, or proceeds from the sale of, the securities held for the account of the Purchaser in accordance with their ownership interests in the Purchaser. Item 7. IDENTIFICATION AND CLASSIFICATION OF SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY Not applicable. Item 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP Not applicable. Item 9. NOTICE OF DISSOLUTION OF GROUP Not applicable. Item 10. CERTIFICATION By signing below we certify that, to the best of our knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect. [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] CUSIP NO. 019777101 Schedule 13G Page 16 of 26 SIGNATURES After reasonable inquiry and to the best of our knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. Dated as of February 17, 2004 PERSEUS-SOROS BIOPHARMACEUTICAL FUND, L.P. By: Perseus-Soros Partners, LLC General Partner By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel CUSIP NO. 019777101 Schedule 13G Page 17 of 26 PERSEUS-SOROS PARTNERS, LLC By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel PERSEUS BIOTECH FUND PARTNERS, LLC By: Perseuspur EC, L.L.C. Managing Member By: Perseuspur, LLC Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer SFM PARTICIPATION, L.P. By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel CUSIP NO. 019777101 Schedule 13G Page 18 of 26 SFM AH LLC By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel PERSEUS EC, L.L.C. By: Perseuspur, LLC Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer PERSEUSPUR, LLC By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer MR. FRANK H. PEARL By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Attorney-in-Fact (1) MR. GEORGE SOROS By: /s/ Jodye M. Anzalotta ---------------------------------------- Name: Jodye M. Anzalotta Title: Attorney-in-Fact (2) CUSIP NO. 019777101 Schedule 13G Page 19 of 26 SOROS FUND MANAGEMENT LLC By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel - ------------------------ (1) A Power of Attorney, dated April 9, 2003, appointing Rodd Macklin to act on behalf of Frank Pearl has been filed with the Securities and Exchange Commission. (2) A Power of Attorney, dated October 30, 2002, appointing each of Armando T. Belly, Jodye Anzalotta, John F. Brown, Maryann Canfield, Richard D. Holahan, Jr. and Robert Soros to act on behalf of George Soros has been filed with the Securities and Exchange Commission. CUSIP NO. 019777101 Schedule 13G Page 20 of 26 EXHIBIT INDEX ------------- Exhibit 1. Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended. Exhibit 2. Power of Attorney, dated October 30, 2002 appointing each of Armando T. Belly, Jodye Anzalotta, John F. Brown, Maryann Canfield, Richard D. Holahan, Jr. and Robert Soros as Attorney-In-Fact for George Soros. Exhibit 3. Power of Attorney, dated April 9, 2003, appointing Rodd Macklin as Attorney-in-Fact for Frank H. Pearl. EX-99 3 ex1_sc13ga1-allos.txt EXHIBIT 1 CUSIP NO. 019777101 Schedule 13G Page 21 of 26 EXHIBIT 1 --------- JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate. Dated as of February 17, 2004 PERSEUS-SOROS BIOPHARMACEUTICAL FUND, L.P. By: Perseus-Soros Partners, LLC General Partner By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel CUSIP NO. 019777101 Schedule 13G Page 22 of 26 PERSEUS-SOROS PARTNERS, LLC By: SFM Participation, L.P. Managing Member By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel PERSEUS BIOTECH FUND PARTNERS, LLC By: Perseuspur EC, L.L.C. Managing Member By: Perseuspur, LLC Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer SFM PARTICIPATION, L.P. By: SFM AH LLC General Partner By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel CUSIP NO. 019777101 Schedule 13G Page 23 of 26 SFM AH LLC By: Soros Fund Management LLC Managing Member By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel PERSEUS EC, L.L.C. By: Perseuspur, LLC Member By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer PERSEUSPUR, LLC By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Secretary and Treasurer MR. FRANK H. PEARL By: /s/ Rodd Macklin --------------------------------------- Name: Rodd Macklin Title: Attorney-in-Fact (1) MR. GEORGE SOROS By: /s/ Jodye M. Anzalotta ---------------------------------------- Name: Jodye M. Anzalotta Title: Attorney-in-Fact (2) CUSIP NO. 019777101 Schedule 13G Page 24 of 26 SOROS FUND MANAGEMENT LLC By: /s/ Jodye M. Anzalotta -------------------------------------- Name: Jodye M. Anzalotta Title: Assistant General Counsel - ------------------------ (1) A Power of Attorney, dated April 9, 2003, appointing Rodd Macklin to act on behalf of Frank Pearl has been filed with the Securities and Exchange Commission. (2) A Power of Attorney, dated October 30, 2002, appointing each of Armando T. Belly, Jodye Anzalotta, John F. Brown, Maryann Canfield, Richard D. Holahan, Jr. and Robert Soros to act on behalf of George Soros has been filed with the Securities and Exchange Commission. EX-24 4 ex2_sc13ga1-allos.txt EXHIBIT 2 CUSIP NO. 019777101 Schedule 13G Page 25 of 26 EXHIBIT 2 --------- POWER OF ATTORNEY KNOW ALL MEN BY THESE PRESENT, that I, GEORGE SOROS, hereby make, constitute and appoint each of Armando T. Belly, Jodye Anzalotta, JOHN F. BROWN, Maryann Canfield, Richard D. Holahan, Jr. and Robert Soros acting individually, as my agent and attorney-in-fact for the purpose of executing in my name, (a) in my personal capacity or (b) in my capacity as Chairman of, member of or in other capacities with Soros Fund Management LLC ("SFM LLC") and each of its affiliates or entities advised by me or SFM LLC, all documents, certificates, instruments, statements, filings and agreements ("documents") to be filed with or delivered to any foreign or domestic governmental or regulatory body or required or requested by any other person or entity pursuant to any legal or regulatory requirement relating to the acquisition, ownership, management or disposition of securities, futures contracts, or other investments, and any other documents relating or ancillary thereto, including but not limited to, all documents relating to filings with the Commodities Futures Trading Commission and National Futures Association, the United States Securities and Exchange Commission (the "SEC") pursuant to the Commodities Exchange Act and the Securities Act of 1933 or the Securities Exchange Act of 1934 (the "Act") and the rules and regulations promulgated thereunder, including all documents relating to the beneficial ownership of securities required to be filed with the SEC pursuant to Section 13(d) or Section 16(a) of the Act and information statements on Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act. All past acts of the attorney-in-fact in furtherance of the foregoing are hereby ratified and confirmed. Execution of this power of attorney revokes that certain Power of Attorney dated as of the 15th day of January 2002 with respect to the same matters addressed above. This power of attorney shall be valid from the date hereof until revoked by me. IN WITNESS WHEREOF, I have executed this instrument as of the 30th day of October, 2002. /s/ George Soros ------------------------------------------- GEORGE SOROS EX-24 5 ex3_sc13ga1-allos.txt EXHIBIT 3 CUSIP NO. 019777101 Schedule 13G Page 26 of 26 EXHIBIT 3 --------- POWER OF ATTORNEY KNOW ALL BY THESE PRESENTS, that I, FRANK H. PEARL, hereby make, constitute and appoint RODD MACKLIN as my agent and attorney-in-fact for the purpose of executing in my name, (a) in my personal capacity or (b) in my capacity as Chairman of, member of or in other capacities with Perseus LLC ("Perseus") and each of its affiliates or entities advised by me or Perseus, all documents, certificates, instruments, statements, filings and agreements ("documents") to be filed with or delivered to any foreign or domestic governmental or regulatory body or required or requested by any other person or entity pursuant to any legal or regulatory requirement relating to the acquisition, ownership, management or disposition of securities, futures contracts, or other investments, and any other documents relating or ancillary thereto, including but not limited to, all documents relating to filings with the Commodities Futures Trading Commission and National Futures Association, the United States Securities and Exchange Commission (the "SEC") pursuant to the Commodities Exchange Act and the Securities Act of 1933 or the Securities Exchange Act of 1934 (the "Act") and the rules and regulations promulgated thereunder, including all documents relating to the beneficial ownership of securities required to be filed with the SEC pursuant to Section 13(d) or Section 16(a) of the Act and information statements on Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act. All past acts of the attorney-in-fact in furtherance of the foregoing are hereby ratified and confirmed. This power of attorney shall be valid from the date hereof until revoked by me. IN WITNESS WHEREOF, I have executed this instrument as of the 9th day of April, 2003. /s/ Frank H. Pearl ------------------------------------------- FRANK H. PEARL -----END PRIVACY-ENHANCED MESSAGE-----